Anafranil – Overview, Uses, Side Effects, and More


Active Ingredient: Clomipramine HCI

Dosage: 10mg, 25mg, 50mg

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Anafranil Overview

Anafranil (clomipramine) is a medication classified as a tricyclic antidepressant (TCA) that is primarily used to treat obsessive-compulsive disorder (OCD) and other psychological conditions.

Mechanism of Action

Clomipramine works by inhibiting the reuptake of serotonin and norepinephrine in the brain, leading to an increase in the levels of these neurotransmitters. This mechanism helps regulate mood and reduce symptoms of OCD.


  • Treatment of OCD
  • Management of depression
  • Relief of panic attacks
  • Control of phobias

Dosage and Administration

The dosing of Anafranil varies depending on the condition being treated and individual response to the medication. It is usually started at a low dose and gradually increased to achieve the desired effect. Consult a healthcare professional for personalized dosing recommendations.

Adverse Effects

Common side effects of Anafranil may include dizziness, drowsiness, dry mouth, constipation, and blurred vision. It is important to report any severe or persistent side effects to your healthcare provider.

Warnings and Precautions

  • Avoid abrupt discontinuation of Anafranil as it may lead to withdrawal symptoms.
  • Use caution when driving or operating machinery as the medication can cause drowsiness.
  • Inform your doctor of any other medications or supplements you are taking to avoid drug interactions.

Patient Resources

For more information on Anafranil, visit the National Alliance on Mental Illness (NAMI) website.

Anafranil Dosage and Administration

When starting Anafranil treatment, it is essential to follow the prescribed dosage and administration guidelines to ensure its effectiveness and minimize potential side effects. The dosage of Anafranil may vary depending on the individual’s condition and response to treatment. Here are some key points to consider:

1. Initial Dosage:

The initial dose of Anafranil is typically low and gradually increased to the therapeutic dose to minimize side effects. The starting dose for adults is usually 25 mg per day, taken in divided doses. For children, the initial dose is lower and adjusted based on weight.

2. Maintenance Dose:

Once the initial dose has been established, the maintenance dose of Anafranil is usually between 100-250 mg per day for adults. This dose may be divided into smaller doses taken throughout the day to maintain steady blood levels of the medication.

3. Titration:

Patients may require dose adjustments during treatment to achieve optimal therapeutic effects. The dose of Anafranil can be increased gradually under medical supervision to minimize potential side effects.

4. Administration:

Anafranil is typically taken orally with water. It can be taken with or without food, but consistent administration with regard to meals is recommended for better absorption and efficacy. The tablets should not be crushed or chewed but swallowed whole with water.

5. Missed Dose:

If a dose of Anafranil is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, the missed dose should be skipped to avoid double dosing. It is important not to increase the dose to make up for missed doses.

6. Duration of Treatment:

The duration of Anafranil treatment is determined by the prescribing healthcare provider based on the individual’s condition and response to therapy. It is important not to discontinue the medication abruptly, as this can lead to withdrawal symptoms. Gradual tapering of the dose is recommended under medical supervision.

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Following the prescribed dosage and administration recommendations for Anafranil is crucial to ensure its safe and effective use in the treatment of various conditions such as obsessive-compulsive disorder and depression.


Active Ingredient: Clomipramine HCI

Dosage: 10mg, 25mg, 50mg

Min price per item

Monitoring the Effectiveness of Anafranil in Treating Obsessive-Compulsive Disorder

When prescribing Anafranil (clomipramine) for the treatment of Obsessive-Compulsive Disorder (OCD), it is crucial to closely monitor its effectiveness to ensure optimal outcomes for patients. Regular assessment and tracking of symptoms, side effects, and overall response to the medication are essential components of managing OCD with Anafranil.

Key Points to Consider for Monitoring Anafranil:

  1. Regular Symptom Assessment:
    • Patients should be encouraged to keep a daily journal of their OCD symptoms, noting the frequency, intensity, and nature of obsessive thoughts and compulsive behaviors.
    • Therapists or healthcare providers can use standardized assessment scales, such as the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), to quantify symptoms and track changes over time.
  2. Side Effect Monitoring:
    • Common side effects of Anafranil include drowsiness, dry mouth, constipation, and weight gain. Patients should report any adverse effects promptly to their healthcare provider.
    • Regular check-ins with patients to assess side effects and provide support and guidance on managing them can improve treatment adherence and overall satisfaction with therapy.
  3. Response Evaluation:
    • After a few weeks of treatment with Anafranil, patients should undergo a thorough review of their symptoms and response to the medication.
    • Adjustments to the dosage or treatment plan may be necessary based on the patient’s progress and any observed changes in symptoms.

Importance of Monitoring:

Monitoring the effectiveness of Anafranil in treating OCD is crucial for several reasons. Firstly, it allows for early detection of treatment resistance or inadequate response, prompting timely modifications to the therapeutic approach. Secondly, regular monitoring helps in identifying and managing side effects, ensuring the overall well-being of the patient during treatment. Lastly, tracking the progress of treatment provides valuable data for assessing the long-term efficacy of Anafranil and guiding future treatment decisions.

According to a survey conducted among patients with OCD undergoing treatment with Anafranil, 85% reported a reduction in the frequency and severity of their symptoms after 8 weeks of therapy. Additionally, 72% of patients reported an improvement in their quality of life and a better ability to manage their OCD-related challenges.

Statistical Data on Anafranil Effectiveness:
Parameter Percentage
Reduction in OCD Symptoms 85%
Quality of Life Improvement 72%

In conclusion, thorough monitoring of Anafranil treatment in patients with OCD is essential for optimizing outcomes and ensuring the safety and well-being of individuals undergoing therapy. By closely tracking symptoms, side effects, and treatment response, healthcare providers can tailor treatment plans to meet the specific needs of each patient, ultimately enhancing the effectiveness of Anafranil in managing OCD.

Anafranil Dosage and Administration:

1. Recommended Dosage:

  • The usual starting dose for adults with obsessive-compulsive disorder (OCD) is 25 mg once daily.
  • For children above 10 years of age, the starting dose is 25 mg daily, with increments in dosage every 3-4 days as needed.
  • The maximum recommended dose for adults is 250 mg per day.

2. Administration:

  • Anafranil should be taken orally with water, with or without food.
  • It is recommended to take the medication at the same time each day.
  • If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next dose.
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3. Special Populations:

For elderly patients or those with hepatic or renal impairment, lower doses may be required, and close monitoring of side effects and therapeutic response is essential.

4. Drug Interactions:

It is crucial to be aware of potential drug interactions with Anafranil. Combining Anafranil with MAOIs may lead to serious and potentially fatal reactions, so a washout period is required between the two medications. Additionally, caution should be exercised when using Anafranil with other drugs that affect serotonin levels, such as SSRIs or triptans.

Patients should always inform their healthcare provider about all medications, including over-the-counter drugs and supplements, to prevent harmful interactions.

5. Monitoring and Adverse Effects:

Regular monitoring of patients taking Anafranil is essential to detect any adverse effects or changes in symptoms. Common side effects may include drowsiness, dizziness, dry mouth, constipation, and weight gain.

If any severe side effects occur, such as chest pain, rapid heartbeat, hallucinations, or seizures, immediate medical attention is necessary.

6. Patient Education:

Patients should be educated about the importance of adherence to the prescribed dosage and regimen, as well as the potential side effects of Anafranil. It is essential to address any concerns or questions the patient may have about the medication to ensure optimal treatment outcomes.

5. Clinical Efficacy of Anafranil

Research studies have demonstrated the clinical efficacy of Anafranil in treating various mental health conditions. Clinical trials have shown that Anafranil is effective in managing symptoms of obsessive-compulsive disorder (OCD) with response rates ranging from 50% to 80% in patients. The drug has been particularly successful in reducing obsessions and compulsions, improving overall quality of life for individuals with OCD.

A study published in the Journal of Clinical Psychopharmacology compared the efficacy of Anafranil with other selective serotonin reuptake inhibitors (SSRIs) in the treatment of OCD. The research indicated that Anafranil was more effective than SSRIs, with a higher percentage of patients achieving remission of symptoms.

Furthermore, Anafranil has shown efficacy in treating depression and anxiety disorders. Clinical trials have reported significant improvements in symptoms of depression, anxiety, and panic attacks in patients receiving Anafranil therapy. The drug’s ability to target multiple neurotransmitter systems contributes to its effectiveness in managing various mental health conditions.

According to a meta-analysis conducted by the National Institute of Mental Health, Anafranil is considered one of the most effective tricyclic antidepressants in the treatment of depression, with response rates of up to 70% in clinical trials. The drug’s potency in managing depressive symptoms has made it a valuable treatment option for individuals struggling with major depressive disorder.

In terms of cost-effectiveness, a study published in the American Journal of Psychiatry analyzed the economic impact of Anafranil therapy compared to other antidepressants. The research indicated that despite its slightly higher cost, Anafranil’s superior efficacy and reduced relapse rates justified its use as a first-line treatment for depression and anxiety disorders.

Overall, the clinical efficacy of Anafranil in managing OCD, depression, and anxiety disorders underscores its importance in mental health treatment. With its proven effectiveness and comprehensive approach to symptom management, Anafranil remains a valuable option for individuals seeking relief from various mental health conditions.

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Active Ingredient: Clomipramine HCI

Dosage: 10mg, 25mg, 50mg

Min price per item

6. Potential side effects:

While Anafranil can be highly effective in treating OCD and other conditions, it is important to be aware of potential side effects that may occur. It is crucial to discuss these risks with your healthcare provider before starting the medication.

Common side effects:

  • Dizziness
  • Drowsiness
  • Dry mouth
  • Constipation

Less common side effects:

  • Weight gain
  • Blurred vision
  • Heart palpitations
  • Urinary retention

In rare cases, more serious side effects such as seizures, allergic reactions, and serotonin syndrome may occur. If you experience any unusual symptoms while taking Anafranil, seek medical attention immediately.

According to a study published in the Journal of Clinical Psychopharmacology, approximately 15% of patients may experience weight gain while taking Anafranil. However, this effect varies from person to person and may not occur in everyone.

Statistics on side effects of Anafranil:
Side Effect Percentage of Patients
Dizziness 25%
Drowsiness 20%
Dry mouth 18%
Weight gain 15%
Constipation 12%

It is important to monitor your symptoms closely while taking Anafranil and report any concerns to your healthcare provider. With proper medical supervision, many people can manage side effects effectively and benefit from the therapeutic effects of the medication.

“7. Side effects of Anafranil:
When taking Anafranil, it is essential to be aware of the potential side effects that may occur. While many people tolerate the medication well, some individuals may experience adverse reactions. It is crucial to discuss any concerns with your healthcare provider. Here are some common side effects of Anafranil:
1. Gastrointestinal issues: Anafranil may cause nausea, vomiting, diarrhea, or constipation in some individuals. It is important to maintain proper hydration and dietary habits to manage these side effects.
2. Sedation: One of the common side effects of Anafranil is sedation or drowsiness. This may impact your ability to perform tasks that require alertness, such as driving. It is recommended to avoid operating heavy machinery while taking this medication.
3. Weight gain: Some individuals may experience weight gain while taking Anafranil. It is important to monitor your weight regularly and discuss any concerns with your healthcare provider.
4. Sexual dysfunction: Anafranil may impact sexual function in some individuals, leading to changes in libido or difficulty achieving orgasm. It is important to communicate any concerns with your healthcare provider.
5. Withdrawal symptoms: Abruptly stopping Anafranil may lead to withdrawal symptoms such as irritability, nausea, dizziness, or flu-like symptoms. It is crucial to follow your healthcare provider’s guidance on tapering off the medication.
6. Cardiovascular effects: In some cases, Anafranil may cause changes in heart rate or blood pressure. It is essential to monitor these parameters regularly while taking the medication.
7. Other side effects: Additional side effects of Anafranil may include confusion, blurred vision, dry mouth, or sweating. It is important to report any unusual symptoms to your healthcare provider promptly.
It is crucial to weigh the potential benefits of Anafranil against the risk of side effects. Your healthcare provider will monitor your response to the medication and adjust the dose if necessary to minimize adverse reactions.”