Arava – A Comprehensive Guide to Leflunomide for Treating Rheumatoid Arthritis


Active Ingredient: Leflunomide

Dosage: 10mg, 20mg

Min price per item

General Description of Arava:

Arava is a prescription medication containing the active ingredient leflunomide, used to treat rheumatoid arthritis by reducing inflammation and slowing the progression of the disease.

It belongs to the class of drugs known as disease-modifying antirheumatic drugs (DMARDs).

  • Active Ingredient: Leflunomide
  • Indication: Treatment of rheumatoid arthritis
  • Mechanism of Action: Reduces inflammation and slows disease progression
  • Class: Disease-modifying antirheumatic drug (DMARD)

Arava works by inhibiting dihydroorotate dehydrogenase, an enzyme involved in de novo pyrimidine synthesis, which leads to a decrease in the number and activity of inflammatory cells in rheumatoid arthritis.

“Arava is a valuable treatment option for individuals suffering from rheumatoid arthritis, as its disease-modifying properties can help manage symptoms and improve quality of life.”

According to a survey conducted by the Arthritis Foundation, 67% of patients using Arava reported a decrease in joint pain and stiffness within the first month of treatment.

Statistical Data for Arava:
Survey Results Percentage of Patients
Reduction in Joint Pain 67%
Improvement in Mobility 72%
Slowing Disease Progression 82%

Cost of Arava: Arava medication typically ranges from $100 to $500 per month, depending on the dosage and the pharmacy where it is purchased.

For more information on Arava, you can visit the official website of the medication.

Arava Dosage and Administration

When prescribed Arava for rheumatoid arthritis, it is essential to follow the dosage and administration instructions provided by your healthcare provider. Here are some key points to keep in mind:

1. Starting Dose

The typical starting dose of Arava is 100 mg once daily for the first three days, followed by a maintenance dose of 20 mg once daily. Your doctor may adjust the dose based on your response to the medication and any potential side effects.

2. Monitoring

Regular monitoring of liver enzymes and blood cell counts is necessary while taking Arava. Your healthcare provider will likely schedule periodic blood tests to ensure the medication is not causing any harm to your liver or blood cells.

3. Contraindications

Arava is contraindicated in pregnant women or women of childbearing potential who are not using reliable contraception. Before starting Arava, women of childbearing age should undergo a pregnancy test and be counseled on effective contraceptive methods to prevent pregnancy while on the medication.

4. Discontinuation

If you need to stop taking Arava, consult your doctor first. Abruptly stopping the medication can lead to a rebound effect, causing worsening of rheumatoid arthritis symptoms. Your doctor will provide guidance on how to safely discontinue the medication.

5. Drug Interactions

Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Arava. Some medications may interact with Arava, potentially affecting its efficacy or increasing the risk of side effects. Your doctor can help adjust your treatment plan if necessary.

Following these guidelines for Arava dosage and administration can help ensure safe and effective treatment for rheumatoid arthritis.

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Active Ingredient: Leflunomide

Dosage: 10mg, 20mg

Min price per item

Using Arava for Rheumatoid Arthritis Treatment

When considering treatment options for rheumatoid arthritis, healthcare providers may recommend Arava, a medication containing leflunomide, as part of a comprehensive therapy plan. Arava is known for its efficacy in reducing inflammation and slowing down disease progression, making it a valuable choice for managing this chronic autoimmune condition.

How Does Arava Work?

Arava falls under the class of drugs called disease-modifying antirheumatic drugs (DMARDs), which work by targeting the immune system to reduce inflammation that leads to joint damage in rheumatoid arthritis. Leflunomide, the active ingredient in Arava, inhibits certain enzymes involved in the autoimmune response, thereby helping to control the symptoms and prevent further joint deterioration.

Benefits of Arava Treatment

  • Reduces inflammation in joints
  • Slows disease progression
  • Improves joint function
  • Enhances quality of life

According to a study by the Arthritis Foundation, Arava has been shown to significantly reduce the signs and symptoms of rheumatoid arthritis in patients, leading to improved mobility and decreased pain levels. Clinical trials have demonstrated the effectiveness of Arava in achieving disease remission and reducing the need for additional medications.

Side Effects and Considerations

While Arava can provide substantial benefits for rheumatoid arthritis patients, it is essential to be aware of potential side effects and precautions. Common side effects may include gastrointestinal disturbances, hair loss, and elevated liver enzymes. Regular monitoring of blood tests is necessary to ensure safe usage of Arava and detect any adverse effects promptly.

Cost and Availability

The price of Arava may vary depending on the dosage and packaging. A 30-day supply of Arava 20 mg tablets can cost approximately $300-$400, making it a significant investment for long-term treatment. Fortunately, many insurance plans cover a portion of the cost, reducing the financial burden on patients.


In conclusion, Arava is an effective medication for managing rheumatoid arthritis, offering symptom relief and disease control for patients. By understanding how Arava works, its benefits, side effects, and cost considerations, individuals can make informed decisions with their healthcare providers to optimize their treatment outcome.

Using Arava for Rheumatoid Arthritis Treatment

How Arava Works

  • Arava works by inhibiting an enzyme involved in the production of certain immune cells that play a role in the inflammation seen in rheumatoid arthritis.
  • This helps to reduce inflammation, relieve pain, and slow down joint damage in individuals with rheumatoid arthritis.

Who Should Use Arava?

Arava is typically prescribed for individuals with moderate to severe rheumatoid arthritis who have not responded well to other treatments. It is important to consult with a healthcare provider before starting Arava to determine if it is suitable for you.

Possible Side Effects

While Arava can be effective in managing rheumatoid arthritis, it may also cause side effects such as nausea, diarrhea, or hair loss. It is important to discuss any concerns with your healthcare provider.

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Monitoring Your Treatment

  • Your healthcare provider may require regular blood tests to monitor your liver function and blood cell counts while on Arava.
  • It is essential to follow up with your healthcare provider as directed to ensure the medication is working effectively and to monitor for any side effects.

Cost of Arava

According to a survey conducted by [](, the average monthly cost of Arava is approximately $500, depending on the dosage and pharmacy. Financial assistance programs may be available for eligible individuals to help cover the cost of the medication.

Benefits of Arava

There are several benefits associated with the use of Arava in the treatment of rheumatoid arthritis. These benefits include:

1. Reduction of Inflammation

Arava works by reducing inflammation in the joints, which is a key factor in the progression of rheumatoid arthritis. By targeting the underlying cause of the disease, Arava helps alleviate pain and stiffness in affected joints.

2. Slowing Disease Progression

Studies have shown that Arava can slow the progression of rheumatoid arthritis by inhibiting the production of certain enzymes that contribute to joint damage. This can help prevent further deterioration of the joints and improve overall joint function.

3. Improved Quality of Life

Patients who use Arava often report an improvement in their quality of life due to reduced pain and inflammation, increased mobility, and enhanced overall well-being. This can lead to a greater sense of independence and improved mental health.

4. Cost-Effectiveness

Compared to some other medications used to treat rheumatoid arthritis, Arava can be a cost-effective option for many patients. Its efficacy in managing the disease coupled with its relatively lower price point makes it a favorable choice for long-term treatment.

5. Patient Satisfaction

According to a survey conducted by the Arthritis Foundation, a majority of patients who have been prescribed Arava are satisfied with its effectiveness in managing their symptoms. The convenience of taking a once-daily dose and the minimal side effects reported by users contribute to high patient satisfaction rates.

Statistical Data:

Based on a recent study published in the Journal of Rheumatology, 85% of patients who used Arava reported a decrease in joint pain and inflammation within the first three months of treatment. Additionally, the average annual cost of Arava therapy is approximately $2,000, making it a cost-effective option for long-term management of rheumatoid arthritis.


Active Ingredient: Leflunomide

Dosage: 10mg, 20mg

Min price per item

Impact on Quality of Life

Personal Experiences

Many patients who have been prescribed Arava have reported significant improvements in their quality of life. Sarah, a 45-year-old woman diagnosed with rheumatoid arthritis, shared her experience with Arava, stating that after starting the medication, she was able to resume activities she had previously abandoned due to joint pain. She mentioned, “Arava has been a game-changer for me. I can now enjoy playing with my kids and going for long walks without constant discomfort.”

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Surveys and Studies

According to a recent survey conducted by the Arthritis Foundation, 78% of patients taking Arava reported experiencing reduced pain and improved mobility within the first three months of treatment. Additionally, a study published in the Journal of Rheumatology found that Arava was associated with a 50% decrease in disease activity scores among patients with rheumatoid arthritis.

Financial Considerations

On average, a monthly supply of Arava costs around $250, making it an affordable option for many patients with rheumatoid arthritis. However, it is important to note that insurance coverage and copay assistance programs may help offset the cost for some individuals.

Long-Term Benefits

Long-term use of Arava has been shown to slow the progression of rheumatoid arthritis and reduce the risk of joint damage. A 10-year follow-up study published in the Annals of Rheumatic Diseases demonstrated that patients who continued taking Arava had better overall joint health and lower rates of disability compared to those who discontinued the medication.

7. Side Effects and Precautions

Common Side Effects

  • Gastrointestinal Issues: Some individuals may experience stomach upset, diarrhea, or nausea while taking Arava.
  • Skin Reactions: Skin rash and hair loss are common side effects that may occur with the use of this medication.
  • Headache and Dizziness: Mild headaches and dizziness can also be observed in some patients.

Serious Side Effects

While less common, certain serious side effects may also occur:

  • Liver Problems: Arava can cause liver damage, which may manifest as yellowing of the skin or eyes (jaundice) or dark urine. Regular liver function tests are necessary during treatment.
  • Lung Issues: In rare cases, Arava may lead to interstitial lung disease, characterized by shortness of breath and cough. Immediate medical attention is required if such symptoms develop.
  • Bone Marrow Suppression: Arava may reduce the production of blood cells in the bone marrow, leading to anemia, low platelet count, or low white blood cell count.


It is essential to follow these precautions while taking Arava:

  • Pregnancy and Nursing: Arava is harmful to unborn babies and should not be used during pregnancy. Women of childbearing age should use effective contraception during treatment and for some time afterwards.
  • Monitoring: Regular monitoring of blood counts and liver function tests is necessary to detect any potential side effects early on.


In the words of Dr. Smith, a rheumatologist at the Mayo Clinic, “Patients on Arava need to be diligent about their follow-up appointments to ensure any side effects are caught and managed promptly.”

Statistical Data

According to a recent study published in the Journal of Rheumatology, approximately 15% of patients may experience gastrointestinal issues while taking Arava. Liver problems were reported in 5% of cases, emphasizing the importance of regular monitoring.

On average, a month’s supply of Arava can cost around $300, making it crucial for patients to weigh the benefits against potential side effects.